clock.bio is building the leading platform for human rejuvenation.
We are decoding the rejuvenation genome, the complete set of genes that enable cells to reverse aging, and validating interventions that replicate this process across multiple organs. Our goal is to deliver real solutions to extend healthspan and improve quality of life.
Our initial focus on skin rejuvenation topicals and nutraceuticals allows us to move quickly, generate human data, and demonstrate measurable reversal of biological age.
Powered by proprietary technologies, our high-throughput discovery platform combines target gene discovery, AI-driven cell age measurement, and next-generation clinical validation to transform the science of aging into interventions.
clock.bio is building the leading platform for human rejuvenation.
We are decoding the rejuvenation genome, the complete set of genes that enable cells to reverse aging, and validating interventions that replicate this process across multiple organs. Our goal is to deliver real solutions to extend healthspan and improve quality of life.
Our initial focus on skin rejuvenation topicals and nutraceuticals allows us to move quickly, generate human data, and demonstrate measurable reversal of biological age.
Powered by proprietary technologies, our high-throughput discovery platform combines target gene discovery, AI-driven cell age measurement, and next-generation clinical validation to transform the science of aging into interventions.
Our mission
We are dedicated to extending human healthspan by developing regenerative therapies that reverse the hallmarks of aging.
By pioneering a new scientific field we call rejuvenation biology, clock.bio is unlocking the body’s innate ability to renew and restore itself at the cellular level and redefining how we approach aging. Our mission is to extend the healthy human lifespan by reversing cellular aging rather than simply slowing it down.
Instead of treating age-related diseases after they emerge, we focus upstream by identifying and targeting the genetic programs of the rejuvenation genome that reverse aging at its source.
To bring rejuvenation interventions to people faster, we’re starting with regenerative topical and nutraceutical applications and expanding toward systemic therapies that can reshape the future of healthspan.
Our approach
We take a systematic and unbiased scientific approach to uncover the genetic mechanisms driving human aging and rejuvenation.
We discovered that human induced pluripotent stem cells (iPSCs) can be forced to age and then spontaneously rejuvenate.
This natural and unique ability to reset the cellular clock reveals a powerful biological mechanism, one that exposes an uncharted layer of cellular plasticity with immense therapeutic potential.
Building on this stem cell breakthrough, we developed a platform that is mapping the rejuvenation genome, identifying the genes and gene programs responsible for rejuvenation through genome-wide CRISPR screens in human iPSCs. We then test the most promising interventions in somatic cell types representing the major organ systems, validating which interventions reverse cellular age and mapping these effects to age-related diseases.
By starting with topical and nutraceutical interventions, we can rapidly generate human data and establish early adoption while building the scientific foundation for future systemic healthspan therapeutics.
Our platform
clock.bio’s platform integrates three proprietary pillars that work together to discover, measure, and translate the biology of human rejuvenation.
geneAge Atlas of Aging and Rejuvenation Genes
The definitive map of the Rejuvenation Genome.
Our Atlas is the scientific foundation of our platform and the world’s first genome-wide map of genes that make up the Rejuvenation Genome. Developed through CRISPR screening in a proprietary human stem cell model, our Atlas has assessed the impact of >20k genes on cell age and identified 151 key genetic targets that drive age-related decline and unlock the pathways for cellular rejuvenation.
imAge
AI-powered measurement of biological age from a single cell image.
ImAge is our proprietary AI learning model that calculates a cell’s biological age in vitro from a single microscope image. This enables high-throughput, image-based screening of any compound or intervention targeting cellular aging and renewal pathways.
clinAge Platform
Human trial platform for validation of rejuvenation therapies.
clinAge is our next-generation clinical trial testing engine designed for adaptive and rapid validation of rejuvenation interventions in humans, starting with skin topicals and nutraceuticals, then scaling to systemic therapies aimed at extending healthspan.
Together, clock.bio’s geneAge Atlas of Aging and Rejuvenation, imAge, and clinAge Platform form an integrated rejuvenation biology engine that moves seamlessly from genetic discovery through in vitro insights to human validation with unmatched speed, precision, and translational potential.
Bringing It All Together: Decoding the Rejuvenation Genome for Real-World Impact
We have built a platform unmatched in its ability to model aging in human cells, decode the rejuvenation genome to pinpoint genetic drivers of aging, and rapidly validate what can reverse it. Our geneAge Atlas provides the map of rejuvenation biology, our imAge platform is the compass to navigate and test interventions, and our clinAge platform enables fast in-human iteration.
clock.bio’s approach is uniquely fast, functional, and built for translation. By combining deep biology, AI-powered measurement, and real-world validation, we are unlocking the rejuvenation genome and delivering the next generation of healthspan therapeutics.
The challenges
clock.bio’s approach
Rejuvenation biology remains largely unknown
We have conducted unbiased CRISPR perturbations to uncover the rejuvenation biology of pluripotent stem cells in less than 12 months
No regulatory framework for rejuvenation/aging interventions
We focus on PoC in skin rejuvenation and nutraceuticals; both have clear regulatory pathways
Novel drugs against new targets pose unknown and potentially severe safety risks
We focus combinations of safe repurposed drugs and supplements
Unknown how many drugs compounds are able to modulate age
Assessing random libraries of approved drugs using our imAge platform indicates that ca -15% drugs are able to modulate age
Unknown whether in vitro findings translates into human clients
Skin rejuvenation is measurable and has a rapid readout; clinAge is designed for rapid iteration
Bringing It All Together: Decoding the Rejuvenation Genome for Real-World Impact
We have built a platform unmatched in its ability to model aging in human cells, decode the rejuvenation genome to pinpoint genetic drivers of aging, and rapidly validate what can reverse it. Our geneAge Atlas provides the map of rejuvenation biology, our imAge platform is the compass to navigate and test interventions, and our clinAge platform enables fast in-human iteration.
clock.bio’s approach is uniquely fast, functional, and built for translation. By combining deep biology, AI-powered measurement, and real-world validation, we are unlocking the rejuvenation genome and delivering the next generation of healthspan therapeutics.