clock.bio aims to extend and improve quality of life by reversing the harmful effects of time in our cells, harnessing the regenerative capabilities of human pluripotent stem cells

clock.bio aims to extend and improve quality of life by reversing the harmful effects of time in our cells, harnessing the regenerative capabilities of human pluripotent stem cells

Our vision

Our vision is to increase human healthspan by developing novel treatments that can prevent and treat age-related diseases.

To do so, we decode the rejuvenation programs present in human cells.

Our approach

We have found that hiPSCs have the ability not only to stay young but also to rejuvenate when forced to age.

Our approach is to harness this power of ‘resetting the clock’ in hiPSCs to identify new approaches to treating age-related diseases.

Our technology

We have developed an aging model that force-ages hiPSCs and triggers their self-rejuvenation mechanism. Unbiased CRISPR screens on large samples of these cells allow us to identify gene candidates that are causally relevant for cell rejuvenation.

Our technology thus enables a comprehensive decoding of rejuvenation biology and corresponding IP. We will use this knowledge to create novel treatment approaches.

Bringing it all together: Our unique approach to decode human rejuvenation biology

The challenges

clock.bio’s unique approach

1

Somatic cells age but cannot rejuvenate. Pluripotent stem cells are the only cells in the human body that can rejuvenate.

Force-age human iPSCs and trigger their self-rejuvenation mechanism.

2

Human aging is a complex process that is difficult to model in cell culture.

Our model delivers 'aging in a dish'.

3

Common approaches can only observe correlations with disease phenotypes over time.

Unbiased CRISPR screens reveal the genes that cause aging/rejuvenation and thus uncover drivers.

4

Human aging is a slow process that typically takes months/years.

Decode the biology of human rejuvenation across the entire genome in 12 months.

Bringing it all together: Our unique approach to decode human rejuvenation biology

1

The challenges

Somatic cells age but cannot rejuvenate. Pluripotent stem cells are the only cells in the human body that can rejuvenate.

clock.bio’s unique approach

Force-age human iPSCs and trigger their self-rejuvenation mechanism.

2

The challenges

Human aging is a complex process that is difficult to model in cell culture.

clock.bio’s unique approach

Our model delivers 'aging in a dish'.

3

The challenges

Common approaches can only observe correlations with disease phenotypes over time.

clock.bio’s unique approach

Unbiased CRISPR screens reveal the genes that cause aging/rejuvenation and thus uncover drivers.

4

The challenges

Human aging is a slow process that typically takes months/years.

clock.bio’s unique approach

Decode the biology of human rejuvenation across the entire genome in 12 months.